MEIS1 encodes a developmental transcription factor and has been linked to restless legs syndrome (RLS) in genome-wide association studies.RLS is a movement disorder leading to severe sleep reduction and has a substantial impact on the quality of life of patients.In genome-wide association studies, MEIS1 has consistently been the gene with the highe
Much effort has been made to remediate the degraded mine lands that bring severe impacts to the natural environments.However, it remains unclear what drives the recovery of biodiversity and ecosystem functions, making the restoration of these fragile ecosystems a big challenge.The interactions among plant species, soil communities, and abiotic cond
Cardiac Na channel remodeling provides a critical substrate for generation of reentrant arrhythmias in border zones of the infarcted canine heart.Recent studies show that Nav1.5 assembly and function are linked to ankyrin-G, gap, and mechanical junction proteins.In this study our objective is to expound the status of the cardiac Na channel, its int